I've recently purchased a cheap Wacom Bamboo tablet for drawing online. I've really taken to doing some pencil work in Sketchbook Pro, and I like doing that a lot. It's easy, intuitive, and great for doing thumbnail sketches and pencilled work. I've had a tougher time with digital inking though... Today I got and downloaded Manga Studio Debut and it's the best time I've had digitally inking so far. I tested it with this drawing of one of my standby characters... He's like a beta testing redneck for me.
Manga Studio has a lot of the elements I love in vector work and am still able to work intuitively with a tablet. I am still going to do inks traditionally as well, but I look forward to working this way as well.